Growth of $10K Avg Annual Total Return %   10 YR 5 YR 1 YR YTD Market Return -- 16.04% 43.54% 18.77% Lipper Pct. Rank -- 22 50 39 NAV Return -- 12.81% 29.50% 11.93% Lipper Pct. Rank -- 39 57 35 Premium/Discount History Premium/Discount 10 YR Avg 5 YR Avg YTD Avg -- -8.967% -4.440%

NAV $23.73 Market Price $23.59 Net Change -$0.05 Market Change -$0.04 Premium/Discount -0.59% 1 YR NAV Return 29.504% 1 YR NAV Rank 57 12-Mo Yield as of 4/30/2021 Yield Def Income Only Yield 0.63% Distribution Yield (Market) 5.73% Most Recent Income Dividend $0.113 Ex-Div Date 5/19/2021 Most Recent Cap Gain Dividend $0.044 Ex-Div Date 12/19/2019 Dividend Frequency Monthly YTD Dividends $0.450 YTD Capital Gains -- Inception Date 7/31/2014 Fund Advisor Tekla Capital Management LLC Manager & Tenure Team Managed Phone 800-426-5523 Website www.teklacap.com Total Net Assets (mil) as of 5/31/2021 $971.5 % Leveraged Assets as of 9/30/2020 21.84% Portfolio Turnover 59.00% Mgmt Fees 1.279% Expense Ratio 2.050% Fund Objective The Fund seeks current income and long-term capital appreciation. Under normal market conditions, the Trust expects to invest at least 80% of its Managed Assets in U.S. and non-U.S. companies engaged in the healthcare industry including equity securities, debt securities, and pooled investment vehicles.

Top Holdings (as of 12/31/2020) Johnson & Johnson ORD 6.44% UnitedHealth Group Inc ORD 6.12% Thermo Fisher Scientific Inc ORD 4.47% Abbvie Inc ORD 4.26% Medtronic PLC ORD 4.19% Abbott Laboratories ORD 3.90% Danaher Corp ORD 3.70% Bristol-Myers Squibb Co ORD 3.66% Merck & Co Inc ORD 3.25% Eli Lilly and Co ORD 2.65%

Top Sectors (as of 12/31/2020) Health Care 86.47% Industrials 6.53% Financials 6.30% Consumer Services 2.60% Non Classified Equity 1.43% Technology 0.00%

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